In vivo evidence for differential association of striatal dopamine and midbrain serotonin systems with neuropsychiatric symptoms in Parkinson's Disease
Identifieur interne : 003312 ( Main/Exploration ); précédent : 003311; suivant : 003313In vivo evidence for differential association of striatal dopamine and midbrain serotonin systems with neuropsychiatric symptoms in Parkinson's Disease
Auteurs : Toshiya Murai [Canada, Allemagne] ; Ulrich Müller ; Katja Werheid ; Dietlind Sorger ; Mike Reuter ; Thomas Becker ; D. Yves Von Cramon ; Henryk BarthelSource :
- The Journal of neuropsychiatry and clinical neurosciences [ 0895-0172 ] ; 2001.
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- Pascal (Inist)
- Wicri :
- topic : Adulte.
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Abstract
Parkinson's disease affects various neurotransmitter systems. Using SPECT, the authors measured [123I]β-CIT binding ratios of the caudate, putamen, medial thalamus, and dorsal midbrain over cerebellum in 16 patients with Parkinson's disease, and examined correlations with clinical ratings. Whereas striatal binding ratios (reflecting regional dopamine transporter densities) were associated with motor symptoms, dorsal midbrain binding ratios (reflecting regional serotonin transporter densities) were significantly correlated with the mentation, behavior, and mood subscale of the Unified Parkinson's Disease Rating Scale. These findings indicate that degeneration of the nigrostriatal dopaminergic neurons and a dysfunctional serotonergic raphe system contribute differentially to motor deficits and neuropsychiatric symptoms in Parkinson's disease.
Affiliations:
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Yves" last="Von Cramon">D. Yves Von Cramon</name></author><author><name sortKey="Barthel, Henryk" sort="Barthel, Henryk" uniqKey="Barthel H" first="Henryk" last="Barthel">Henryk Barthel</name></author></analytic><series><title level="j" type="main">The Journal of neuropsychiatry and clinical neurosciences</title><title level="j" type="abbreviated">J. neuropsychiatr. clin. neurosci.</title><idno type="ISSN">0895-0172</idno><imprint><date when="2001">2001</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The Journal of neuropsychiatry and clinical neurosciences</title><title level="j" type="abbreviated">J. neuropsychiatr. clin. neurosci.</title><idno type="ISSN">0895-0172</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Correlation</term><term>Diagnosis</term><term>Dopamine</term><term>Exploration</term><term>In vivo</term><term>Neuropsychiatry</term><term>Nigrostriatal pathway</term><term>Parkinson disease</term><term>Performance evaluation</term><term>Serotonin</term><term>Severity score</term><term>Statistical analysis</term><term>Symptomatology</term><term>Technique</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Symptomatologie</term><term>Neuropsychiatrie</term><term>Dopamine</term><term>Exploration</term><term>Voie nigrostriatale</term><term>Sérotonine</term><term>Diagnostic</term><term>Indice gravité</term><term>Evaluation performance</term><term>Technique</term><term>Analyse statistique</term><term>Corrélation</term><term>In vivo</term><term>Adulte</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease affects various neurotransmitter systems. Using SPECT, the authors measured [<sup>123</sup>I]β-CIT binding ratios of the caudate, putamen, medial thalamus, and dorsal midbrain over cerebellum in 16 patients with Parkinson's disease, and examined correlations with clinical ratings. Whereas striatal binding ratios (reflecting regional dopamine transporter densities) were associated with motor symptoms, dorsal midbrain binding ratios (reflecting regional serotonin transporter densities) were significantly correlated with the mentation, behavior, and mood subscale of the Unified Parkinson's Disease Rating Scale. These findings indicate that degeneration of the nigrostriatal dopaminergic neurons and a dysfunctional serotonergic raphe system contribute differentially to motor deficits and neuropsychiatric symptoms in Parkinson's disease.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li></country></list><tree><noCountry><name sortKey="Barthel, Henryk" sort="Barthel, Henryk" uniqKey="Barthel H" first="Henryk" last="Barthel">Henryk Barthel</name><name sortKey="Becker, Thomas" sort="Becker, Thomas" uniqKey="Becker T" first="Thomas" last="Becker">Thomas Becker</name><name sortKey="Muller, Ulrich" sort="Muller, Ulrich" uniqKey="Muller U" first="Ulrich" last="Müller">Ulrich Müller</name><name sortKey="Reuter, Mike" sort="Reuter, Mike" uniqKey="Reuter M" first="Mike" last="Reuter">Mike Reuter</name><name sortKey="Sorger, Dietlind" sort="Sorger, Dietlind" uniqKey="Sorger D" first="Dietlind" last="Sorger">Dietlind Sorger</name><name sortKey="Von Cramon, D Yves" sort="Von Cramon, D Yves" uniqKey="Von Cramon D" first="D. Yves" last="Von Cramon">D. Yves Von Cramon</name><name sortKey="Werheid, Katja" sort="Werheid, Katja" uniqKey="Werheid K" first="Katja" last="Werheid">Katja Werheid</name></noCountry><country name="Canada"><noRegion><name sortKey="Murai, Toshiya" sort="Murai, Toshiya" uniqKey="Murai T" first="Toshiya" last="Murai">Toshiya Murai</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Murai, Toshiya" sort="Murai, Toshiya" uniqKey="Murai T" first="Toshiya" last="Murai">Toshiya Murai</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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